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ChemicalBook--->CAS DataBase List--->2143896-83-5

2143896-83-5

2143896-83-5 Structure

2143896-83-5 Structure
IdentificationBack Directory
[Name]

PKUMDL-LC-101-D04
[CAS]

2143896-83-5
[Synonyms]

PKUMDL-LC-101-D04
GPX4-Activator-1d4
PKUMDL LC 101 D04,PKUMDL-LC-101-D-04,PKUMDLLC101D04
[Molecular Formula]

C14H23ClN4O2S2
[MOL File]

2143896-83-5.mol
[Molecular Weight]

378.93
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: soluble
[form ]

A crystalline solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4).1 It increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay and at 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts. PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death.
[storage]

Store at -20°C
[References]

1. Li, C., Deng, X., Zhang, W., et al. Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4 J. Med. Chem. 62(1),266-275(2019).
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