| Identification | Back Directory | [Name]
T-2 TOXIN | [CAS]
21259-20-1 | [Synonyms]
toxint2
Toxin T 2
hothecene
nsc138780
T-2 TOXIN
FUSARITOXIN
alerate[qr]
t-2mycotoxin
FUSARIOTOXIN
Insariotoxin
othecene[qr]
-isovalerate
MYCOTOXIN T 2
nsc138780[qr]
8-isovalerate
T-2 LienoMycin
isaritoxin[qr]
fusariotoxinet2
t-2mycotoxin[qr]
trichothec-9-ene
insariotoxin[qr]
FUSARIOTOXIN T 2
T-2TRICHOTHECENE
EPOXYTRICHOTHECENE
a9-tricothecene[qr]
fusariotoxinet2[qr]
12,13-trichothecene
t2-trichothecene[qr]
CAS21259-20-1 T-2 TOXIN
T2 toxin 100ug/ml in ACN
12,13-EPOXYTRICHOTHECENE
T-2-toxin vial with 5 mg
T-2 Toxin (T-2 Mycotoxin)
MYCOTOXIN TRICHOTHECENE 2
t(sub2)-trichothecene[qr]
T-2 toxin from fusarium sp
100 ug/ml T-2 Toxin in ACN
(3alpha,4beta,8alpha)-oate
13C24]-T-2 toxin-25 μg/mL in ACN
Fusariotoxin T2: (T2-Trichothecene)
T-2 Toxin, froM FusariuM tricinctuM
T-2 Toxin, 99%, from Fusarium tricinctum
8-(3-Methylbutyryloxy)diacetoxyscirpenol
8-(3-methylbutyryloxy)-diacetoxyscirpenol
8-(3-methylbutyryloxy)-diacetoxy-scirpeno
Scirpenol, 8-(3-methylbutyryloxy)-diacetoxy-
T-2 Toxin Solution in Acetonitrile, 100μg/mL
8-(3-methylbutyryloxy)-diacetoxyscirpenol[qr]
4,15-diacetoxy-8-(3-methylbutyryloxy)scirp-9-en-3-ol
U-[13C24]-T-2 Toxin Solution in Acetonitrile, 25μg/mL
8α-(3-Methylbutyryloxy)-4β,15-
diacetoxyscirp-9-en-3α-ol
Epoxytrichothecene, Fusariotoxin T 2, Mycotoxin T 2
8alpha-(3-Methylbutyryloxy)-4beta,15-diacetoxyscirp-9-en-3alpha-ol
8alpha-(3-methylbutyryloxy)-4beta,15-diacetoxyscirp-9-en-3alpha-ol[qr]
12,13-epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate
4β,15-Diacetoxy-8α-(3-Methylbutyryloxy)-
12,13-epoxytrichothec-9-en-3α-ol
4beta,8alpha,15-tetrol,12,13-epoxy-,4,15-diacetate8-trichothec-9-ene-3alph
3-hydroxy-4,15-diacetoxy-8-[3-methylbutyryloxy]-12,13-epoxytrichothec-9-ene
4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecen-3-ol
12,13-epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol4,15-diacetate8
3-hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta(sup9)-tric
4-beta,15-diacetoxy-8-alpha-(3-methylbutyryloxy)-3-alpha-hydroxy-12,13-epoxy
T2 Toxin / Fusariotoxin T 2 / Insariotoxin / Mycotoxin T 2
trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-,4,15-diacetate8-(3-methylbutan
trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol,12,13-epoxy-,4,15-diacetate
12,13-epoxytrichothec-9-ene-3,4,8,15-tetrol4,15-diacetate8-(3-methylbutanoate
12,13-epoxytrichothec-9-ene-3alpha,4beta,8alpha,15-tetrol,4,15-diacetate8-isov
3alpha-hydroxy-4beta-15-diacetoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxy-delt
3-hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-(sup9)-trich
4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecen-3-ol[qr
3alpha-Hydroxy-4beta,15-diacetoxy-8alpha(3-methylbutyryloxy)-12,13-epoxy-trichothec-9-ene
4BETA,15-DIACETOXY-3ALPHA-HYDROXY-8ALPHA-[3-METHYLBUTYRYLOXY]-12,13-EPOXYTRICHOTHEC-9-ENE
Trichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate
(3α,4β,8α)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 4,15-Diacetate 8-(3-Methylbutanoate)
Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3α,4β,8α)-
(3alpha,4beta,8alpha)-12,13-epoxytrichothec-9-ene-3,4,8,15-tetrol 4,15-diacetate 8-(3-methylbutyrate)
Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-
(3-ALPHA, 4-BETA, 8-ALPHA)-TRICHOTHEC-9-ENE-3,4,8,15-TETROL,12,13-EPOXY-, 4,15-DIACETATE 8-(3-METHYLBUTANOATE)
(3-alpha, 4-beta, 8-alpha)-Trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), Mycotoxin Trichothecene 2, Fusariotoxin
4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene, 12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate
T-2 Toxin,12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate, 4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene | [EINECS(EC#)]
244-297-7 | [Molecular Formula]
C24H34O9 | [MDL Number]
MFCD00871255 | [MOL File]
21259-20-1.mol | [Molecular Weight]
466.52 |
| Chemical Properties | Back Directory | [Melting point ]
151.5℃ | [alpha ]
D26 +15° (c = 2.58 in ethanol) | [Boiling point ]
489.35°C (rough estimate) | [density ]
1.1942 (rough estimate) | [refractive index ]
1.6230 (estimate) | [Fp ]
2 °C | [storage temp. ]
−20°C
| [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml | [form ]
powder
| [pka]
13.24±0.70(Predicted) | [color ]
white
| [Merck ]
13,9872 | [IARC]
3 (Vol. 31, Sup 7) 1987 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
T-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration. | [Description]
T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC50 = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage. | [Definition]
ChEBI: T-2 toxin is a trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. It has a role as a mycotoxin, a cardiotoxic agent, a neurotoxin, an environmental contaminant, an apoptosis inducer, a DNA synthesis inhibitor and a fungal metabolite. It is a trichothecene, an acetate ester and an organic heterotetracyclic compound. It is functionally related to a HT-2 toxin. | [General Description]
T-2 Toxin is found to be a potent trichothecene mycotoxin produced by the genus fusarium fungi in feedstuffs and cereal grains. |
| Safety Data | Back Directory | [Hazard Codes ]
T+,T,Xn,F | [Risk Statements ]
26/27/28-38-36-20/21/22-11 | [Safety Statements ]
28-36/37-45-36-26-16-36/37/39-22 | [RIDADR ]
UN 3462 6.1/PG 1
| [WGK Germany ]
3
| [RTECS ]
YD0100000
| [F ]
10-21 | [HazardClass ]
6.1(a) | [PackingGroup ]
I | [HS Code ]
29329990 | [Safety Profile]
Poison by ingestion,
intramuscular, subcutaneous, intraperitoneal,
intracerebral, and intravenous routes.
Moderately toxic by inhalation.
Experimental teratogenic and reproductive
effects. A skin irritant. Questionable
carcinogen with experimental neoplastigenic
data. Mutation data reported. When heated
to decomposition it emits acrid smoke and
irritating fumes. | [Hazardous Substances Data]
21259-20-1(Hazardous Substances Data) | [Toxicity]
LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer) |
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