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ChemicalBook--->CAS DataBase List--->2112731-42-5

2112731-42-5

2112731-42-5 Structure

2112731-42-5 Structure
IdentificationBack Directory
[Name]

Mal-amido-PEG7-acid
[CAS]

2112731-42-5
[Synonyms]

Mal-NH-PEG7-acid
Mal-NH-PEG7-COOH
Mal-amido-PEG7-COOH
Mal-amido-PEG7-acid
Mal-amido-PEG7-propionic acid
1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25-heptaoxa-4-azaoctacosan-28-oic acid
4,7,10,13,16,19,22-Heptaoxa-25-azaoctacosanoic acid, 28-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-26-oxo-
[Molecular Formula]

C24H40N2O12
[MDL Number]

MFCD30723255
[MOL File]

2112731-42-5.mol
[Molecular Weight]

548.58
Hazard InformationBack Directory
[Uses]

Mal-amido-peg7-acid is a useful research chemical, a PEG linker and a PEG reagent.
[Biological Activity]

Mal-amido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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