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ChemicalBook--->CAS DataBase List--->211096-49-0

211096-49-0

211096-49-0 Structure

211096-49-0 Structure
IdentificationBack Directory
[Name]

GSK-CXCR2
[CAS]

211096-49-0
[Synonyms]

GSK-CXCR2
SB 265610
SB265610 >=98% (HPLC)
N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea
Urea, N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-
1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea
[Molecular Formula]

C14H9BrN6O
[MDL Number]

MFCD09971124
[MOL File]

211096-49-0.mol
[Molecular Weight]

357.16
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble15mg/mL, clear
[form ]

powder
[color ]

white to light brown
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P280-P305+P351+P338
[Hazard Codes ]

Xn
[Risk Statements ]

22
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

SB 265610 is an anti-tumor pharmaceutical developed to act as an antagonist to cysteine-amino acid-cysteine (CXC) chemokines receptor 2 antagonist.
[Biological Activity]

Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca 2+ mobilization (IC 50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo .
[Biochem/physiol Actions]

SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.
[storage]

Store at RT
Spectrum DetailBack Directory
[Spectrum Detail]

GSK-CXCR2(211096-49-0)1HNMR
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