| Identification | Back Directory | [Name]
ODVWZAKKCNHATB-UHFFFAOYSA-N | [CAS]
2108899-91-6 | [Synonyms]
ODVWZAKKCNHATB-UHFFFAOYSA-N
CPTH2 (hydrochloride) (357649-93-5 free base)
2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone,monohydrochloride | [Molecular Formula]
C14H15Cl2N3S | [MOL File]
2108899-91-6.mol | [Molecular Weight]
328.26 |
| Hazard Information | Back Directory | [Description]
Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. CPTH2 inhibits the HAT activity of Gcn5 both in vitro and in vivo, reducing histone H3K14 acetylation at a concentration of 0.8 mM. It is a useful tool to study the impact of Gcn5-dependent acetylation in various biological systems and recently has been used to control the replication of human adenovirus. |
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