| Identification | Back Directory | [Name]
CP-424,174 | [CAS]
210825-31-3 | [Synonyms]
CP-424,174
CP-424,174 >=98% (HPLC)
N-((4-Chloro-2,6-diisopropylphenyl)carbamoyl)-3-(2-hydroxypropan-2-yl)benzenesulfonamide
CP424174,IL-1β,NLRP3,Inhibitor,CP 424174,CP-424174,Inflammasome,inhibit,NOD-like Receptor (NLR)
N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
Benzenesulfonamide, N-[[[4-chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)- | [Molecular Formula]
C22H29ClN2O4S | [MDL Number]
MFCD30537538 | [MOL File]
210825-31-3.mol | [Molecular Weight]
452.99 |
| Chemical Properties | Back Directory | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml | [form ]
powder | [pka]
4.67±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
CP-424,174 is a cytokine release inhibitory drugs (CRID) that inhibits the post-translational processing and secretion of IL-1b in response to LPS and ATP in human monocytes. It is quite possible that similarly to CP-456,773 (termed CRID3), CP-424,174 inhibits both NLRP3 and AIM2 inflammasomes by preventing ASC oligomerisation. |
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