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ChemicalBook--->CAS DataBase List--->210821-63-9

210821-63-9

210821-63-9 Structure

210821-63-9 Structure
IdentificationBack Directory
[Name]

1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
[CAS]

210821-63-9
[Synonyms]

Org 12692
Org12962HCl
Org 12962 hydrochloride
1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazinehydrochloride
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
[Molecular Formula]

C10H11ClF3N3.ClH
[MOL File]

210821-63-9.mol
[Molecular Weight]

302.126
Chemical PropertiesBack Directory
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

Soluble to 50 mM in water and to 100 mM in DMSO
[form ]

Pale yellow solid.
Hazard InformationBack Directory
[Uses]

Org 12962 Hydrochloride is a receptor agonists that helps in the anxiety models in rats.
[Biological Activity]

Selective 5-HT 2C receptor agonist (pEC 50 values are 7.01, 6.38 and 6.28 for 5-HT 2C , 5-HT 2A and 5-HT 2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.
[in vivo]

Org 12962 (intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects[3].

Animal Model:Male Wistar rats[3]
Dosage:0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Administration:Intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Result:Had a dose-related antipanic-like effect in SD-rat.
[IC 50]

5-HT2C Receptor: 7.01 (pEC50); 5-HT2A Receptor: 6.38 (pEC50); 5-HT2B Receptor: 6.28 (pEC50)
[storage]

Desiccate at RT
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