| Identification | Back Directory | [Name]
Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl- | [CAS]
2102179-29-1 | [Synonyms]
TRPM8 antagonist 3
Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl- | [Molecular Formula]
C13H12N2O4S | [MOL File]
2102179-29-1.mol | [Molecular Weight]
292.31 |
| Chemical Properties | Back Directory | [Boiling point ]
579.7±60.0 °C(Predicted) | [density ]
1.517±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
6.08±0.45(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC50 value of 11 nM. | [References]
[1]. Bianchini G, et al. Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through pKa and LogD Modulation. J Med Chem. 2021 Nov 25;64(22):16820-16837. |
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