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ChemicalBook--->CAS DataBase List--->2093387-50-7

2093387-50-7

2093387-50-7 Structure

2093387-50-7 Structure
IdentificationBack Directory
[Name]

Thalidomide-NH-C4-NH2 TFA
[CAS]

2093387-50-7
[Synonyms]

halidomide-NH-C4-NH2TFA
Pomalidomide-C4-NH2 TFA
Thalidomide-NH-C4-NH2 TFA
Pomalidomide Related Compound 10 Triflate
4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2,2,2-trifluoroacetate
[Molecular Formula]

C19H21F3N4O6
[MDL Number]

MFCD32903491
[MOL File]

2093387-50-7.mol
[Molecular Weight]

458.39
Hazard InformationBack Directory
[Biological Activity]

Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 . PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1].
[References]

[1]. Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies. Bioorg Med Chem. 2020 Jan 1;28(1):115181.
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