| Identification | Back Directory | [Name]
8,10,12,14,19-Docosapentaenoic acid, 7,16,17-trihydroxy-, (7S,8E,10Z,12E,14E,16R,17S,19Z)- | [CAS]
2093111-29-4 | [Synonyms]
8,10,12,14,19-Docosapentaenoic acid, 7,16,17-trihydroxy-, (7S,8E,10Z,12E,14E,16R,17S,19Z)- | [Molecular Formula]
C22H34O5 | [MOL File]
2093111-29-4.mol | [Molecular Weight]
378.5 |
| Hazard Information | Back Directory | [Biological Activity]
Resolvin D2 n-3 DPA (RvD2 n-3 DPA) is a specialized pro-resolving mediator (SPM).1 It is formed from docosapentaenoic acid , an intermediate in the conversion of eicosapentaenoic acid to docosahexaenoic acid , in human leukocytes. RvD2 n-3 DPA (1 nM) reduces TNF-α-induced chemotaxis and adhesion of isolated human neutrophils. In vivo, RvD2 n-3 DPA (100 ng/animal; i.v.) reduces peritoneal neutrophil infiltration and exudate levels of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in a mouse model of zymosan-induced inflammation. | [References]
1.Dalli, J., Colas, R.A., and Serhan, C.N.Novel n-3 immunoresolvents: Structures and actionsSci. Rep.31940(2013)
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