| Identification | Back Directory | [Name]
L-CYSTEINESULFINIC ACID MONOHYDRATE | [CAS]
207121-48-0 | [Synonyms]
3-sulfino-l-alanine
L-Cysteinesulfinic Acid (hydrate)
(2R)-2-aMino-3-sulfinopropanoic acid
L-Cysteinesulfinic acid Monohydrate 99%
(1R)-1-amino-2-mercaptoethanesulfinic acid hydrate | [EINECS(EC#)]
623-116-9 | [Molecular Formula]
HO2SCH2CH(NH2)CO2HH2O | [MDL Number]
MFCD00150732 | [MOL File]
207121-48-0.mol | [Molecular Weight]
171.17 |
| Chemical Properties | Back Directory | [Melting point ]
163 °C (dec.)(lit.)
| [storage temp. ]
-20°C | [solubility ]
Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [optical activity]
[α]25/D +24°, c = 1 in 1 M HCl | [Stability:]
Temperature Sensitive |
| Hazard Information | Back Directory | [Description]
L-Cysteinesulfinic acid is an excitatory amino acid and agonist of metabotropic glutamate receptors (mGluRs).1,2 It increases intracellular inositol phosphate levels in CHO cells expressing mGluR1, mGluR5, or mGluR8 (EC50s = 120, 30, and 110 μM, respectively) and inhibits forskolin-induced cAMP production in CHO cells expressing mGluR2 or mGluR6 and hamster kidney cells expressing mGluR4 (EC50s = 100, 100, and 2,000 μM, respectively).2 It selectively binds to mGluR1α (Ki = 3,510 nM) over adrenergic, dopamine, histamine, muscarinic, nicotinic, or serotonin receptors (Kis = >10,000 nM for all). L-Cysteinesulfinic acid (1 mM) decreases mean arterial blood pressure and heart rate in rats when microinjected into the nucleus tractus solitarius (NTS).1 L-Cysteinesulfinic acid can be formed via oxidation of L-cysteine by reactive oxygen species (ROS), and conversion of cysteine to L-cysteinesulfinic acid in cysteine-containing peptide probes has been used to measure oxidative stress.3 | [Chemical Properties]
Off-White Solid | [Uses]
An amino acid derivative with neuropathological interest; Putative excitatory amino acid neurotransmitter. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Biochem/physiol Actions]
Cysteinesulfinic acid (CSA), also called 3-sulfinoalanine is synthesized by the conversion of sulfur to sulfinic acid in cysteine by the enzyme cysteine dioxygenase (CDO). CSA is a putative excitatory amino acid (EAA) with neurotransmitter functionality. It also regulates cardiovascular functions. |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|