| Identification | Back Directory | [Name]
(S)-A-METHYL-A-[[[(4-NITROPHENYL)AMINO]CARBONYL]AMINO]-N-[[1-(2-PYRIDINYL)CYCLOHEXYL]METHYL]-1H-INDOLE-3-PROPANAMIDE | [CAS]
204066-82-0 | [Synonyms]
PD 168368
(2S)-3-(1H-INDOL-3-YL)-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]-N-[(1-PYRIDIN-2-YLCYCLOHEXYL)METHYL]PROPANAMIDE
(S)-α-Methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-N-[[1-(2-pyridinyl)cyclohexyl]methyl]-1H-indole-3-propanamide
(S)-A-METHYL-A-[[[(4-NITROPHENYL)AMINO]CARBONYL]AMINO]-N-[[1-(2-PYRIDINYL)CYCLOHEXYL]METHYL]-1H-INDOLE-3-PROPANAMIDE
1H-Indole-3-propanamide, α-methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-N-[[1-(2-pyridinyl)cyclohexyl]methyl]-, (αS)- | [Molecular Formula]
C31H34N6O4 | [MDL Number]
MFCD09971100 | [MOL File]
204066-82-0.mol | [Molecular Weight]
554.64 |
| Chemical Properties | Back Directory | [Boiling point ]
819.7±65.0 °C(Predicted) | [density ]
1.300±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMF: 10 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml | [form ]
A crystalline solid | [pka]
11.60±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
Potent neuromedin B receptor antagonist (NMB-R, BB 1 ) (IC 50 = 40 nM) that displays ~ 40-fold selectivity over the gastrin-releasing peptide receptor (GRP-R, BB 2 ) and > 300-fold selectivity over BRS-R (bb 3 ). Antagonizes neuromedin B-stimulated calcium release and inhibits proliferation of rat glioma cells (IC 50 = 2 μ M). | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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https://www.bocsci.com |
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