| Identification | Back Directory | [Name]
AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2 | [CAS]
200959-48-4 | [Synonyms]
Ac-RYYRIK-NH
AC-RYYRIK-NH2
Ac-RYYRIK amide
ACETYL-RYYRIK, AMIDE
AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2
N2-Acetyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-arginyl-L-isoleucyl-L-lysinamide
L-Lysinamide, N2-acetyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-arginyl-L-isoleucyl- | [Molecular Formula]
C44H70N14O9 | [MDL Number]
MFCD02262126 | [MOL File]
200959-48-4.mol | [Molecular Weight]
939.11 |
| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C
| [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
9.82±0.15(Predicted) |
| Hazard Information | Back Directory | [Biological Activity]
Ac-RYYRIK-NH2 is a potent ORL1 partial agonist as an endogenous ligand of ORL1 in CHO cells (Kd=1.5 nM). Ac-RYYRIK-NH2 is a specific antagonist of G protein activation and competitively antagonizes noc/OFQ-stimulated [35S]-GTPgS-binding G protein in rat meninges and brain sections. | [in vivo]
Ac-RYYRIK-NH2 (intracerebroventricularly (icv) inhibits spontaneous locomotor activity in mice with an ID 50 of 0.07 nmol. Co-administration of noc/OFQ and Ac-RYYRIK-NH2 | [target]
Kd: 1.5 nM (ORL1 transfected in CHO cells) | [storage]
Desiccate at -20°C |
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