| Identification | Back Directory | [Name]
H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH | [CAS]
191936-91-1 | [Synonyms]
TAT (47-57)
YGRKKRRQRRR
HIV-1 Tat (47-57)
HIV-I TAT Protein Peptide
HIV-1 TAT PROTEIN (47-57)
HIV-1 TAT PROTEIN PEPTIDE
TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG
H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH
TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG: YGRKKRRQRRR
H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH USP/EP/BP
L-Arginine, L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl- | [Molecular Formula]
C64H118N32O14 | [MDL Number]
MFCD07366706 | [MOL File]
191936-91-1.mol | [Molecular Weight]
1559.83 |
| Chemical Properties | Back Directory | [density ]
1.54±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
deionized water: soluble | [form ]
lyophilized powder | [biological source]
synthetic | [Water Solubility ]
deionized water: soluble |
| Hazard Information | Back Directory | [Uses]
TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins | [General Description]
HIV-1 trans-activator of transcription (Tat) is an 11kDa protein, which regulates HIV-1 gene expression at the level of transcription and protein synthesis. It is located in the nucleus of infected cells. HIV-1 Tat functions as a transcriptional activator for the synthesis of full-length viral RNA. It induces RNA splicing. Tat is an RNA binding protein, which particularly recognizes trans activator response element (TAR) from the HIV-1 RNA molecule. | [Biochem/physiol Actions]
Synthetic peptide that includes the sequence responsible for the cellular uptake of the human immunodeficiency virus-1 Tat protein, consisting of the polycationic region 49–57. The peptide is part of the protein transduction domain (PTD) and was shown to enable the introduction of nucleic acids into cells. | [IC 50]
HIV-1 | [storage]
Store at -20°C | [References]
[1] NICOLAS CHARNAY. Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein.[J]. ACS Applied Bio Materials, 2009: 74. DOI:10.1186/1742-4690-6-74.
[2] ASEN BAGASHEV Bassel E S. Roles and functions of HIV-1 Tat protein in the CNS: an overview.[J]. ACS Applied Energy Materials, 2013: 358. DOI:10.1186/1743-422X-10-358.
[3] NANCY MUELLER. The HIV-1 Tat Protein Enhances Splicing at the Major Splice Donor Site.[J]. ACS Applied Energy Materials, 2018. DOI:10.1128/JVI.01855-17.
[4] ESTEBAN CRUZ Veysel K. Synthesis and Enhanced Cellular Uptake In Vitro of Anti-HER2 Multifunctional Gold Nanoparticles.[J]. ACS Applied Energy Materials, 2019. DOI:10.3390/cancers11060870.
[5] ANDRé ZIEGLER Joachim S. Interaction of the protein transduction domain of HIV-1 TAT with heparan sulfate: binding mechanism and thermodynamic parameters.[J]. Biophysical journal, 2004, 86 1 Pt 1: 254-263. DOI:10.1016/S0006-3495(04)74101-6. |
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