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ChemicalBook--->CAS DataBase List--->1916-59-2

1916-59-2

1916-59-2 Structure

1916-59-2 Structure
IdentificationBack Directory
[Name]

3-aminophenoxazone
[CAS]

1916-59-2
[Synonyms]

Phx-3
Questiomycin A
2-Aminophenoxazon
3-aminophenoxazone
2-AMino-3-phenoxazone
2-amino-1H-phenoxazin-3-one
2-Amino-3-oxo-3H-phenoxazine
3H-Phenoxazin-3-one, 2-aMino-
2-AMino-3H-phenoxazin-3-one, 2-AMinophenoxazone, AV Toxin C, NSC 94945
[Molecular Formula]

C12H8N2O2
[MDL Number]

MFCD00207317
[MOL File]

1916-59-2.mol
[Molecular Weight]

212.2
Chemical PropertiesBack Directory
[Melting point ]

249-250 °C
[Boiling point ]

352.04°C (rough estimate)
[density ]

1.2399 (rough estimate)
[refractive index ]

1.6000 (estimate)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 2mg/mL; DMSO: 3mg/mL; DMSO:PBS (pH 7.2) (1:20): 0.04mg/mL
[form ]

A solid
[pka]

2.73±0.20(Predicted)
Hazard InformationBack Directory
[Description]

Questiomycin A is a phenoxazine and a chromophore that has been found in Streptomyces and has antibacterial and anticancer activities. It is active against M. scrofulaceum, M. marinum, and M. intracellulare (MICs = 2.8, 11.3, and 5.6 μg/ml, respectively) but not M. tuberculosis, M. smegmatis, M. kansasii, or M. fortuitum (MICs = >45 μg/ml). It is also inactive against E. coli, P. aeruginosa, S. tymphimurium, S. aureus, or L. monocytogenes. It is cytotoxic to a variety of cancer cells, including MCF-7, A549, MIA PaCa-2, and LoVo-1 cells (IC50s = 1.67, 5.48, 7.16, and 20.03 μM, respectively) as well as human umbilical vein endothelial cells (HUVECs) but not human embryonic lung fibroblast cells (HELs; IC50s = 16.06 and >50 μM, respectively). Questiomycin A reduces the increased intracellular pH in a variety of cancer cell lines, as well as in HUVECs and HELs. It prevents lung metastasis in a B16 mouse melanoma model of metastasis when administered at a dose of 0.5 mg/kg simultaneously with B16 cells or every three days. It is also a chromophore product of the reducing agent 2-aminophenol oxidation (as 2-amino-phenoxazine-3-one) and has been used as a readout in the study of catalytic oxidation of 2-aminophenol by various metal-containing complexes. It has an absorbance of 435 nm in methanol.
[Uses]

Questiomycin A is a natural antimicrobial agent produced by agriculturally important species such as maize, rye, and wheat.
[Uses]

Questiomycin A is a phenoxazine produced by several Streptomyces species and some fungi and bacteria. Questiomycin A is weakly active against bacteria, fungi, plants and tumour cell lines, and inhibits aromatase and sulfatases. Questiomycin, like other phenoxazines, stimulates cell growth and turnover in vitro, an activity possibly related to their ability to form stable free radicals. More recently, questiomycin A has been shown to inhibit pulmonary metastasis caused by mouse melanoma cells. Questiomycin A and related phenoxazines are important dereplication standards in discovery research to eliminate leads due to high amounts of weakly potent actives.
[Definition]

ChEBI:2-aminophenoxazin-3-one is a phenoxazine.
[storage]

Store at -20°C
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