| Identification | Back Directory | [Name]
BenzenaMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]- | [CAS]
190728-25-7 | [Synonyms]
4-(6,7-Dimethoxy-quinoL
Intermediate 1 of Cabozantinib
Cabozantinib Genotoxic Impurity I
4-[(6,7-dimethoxy-4-quinolinyl)oxy]-
4-(6,7-dimethoxy quinolinoxy) aniline
4-(4-Aminophenoxy)-6,7-dimethoxyquinoline
6,7-Dimethoxy-4-(4-aminophenoxy)quinoline
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
6,7-Dimethoxy-4-(4-aminophenyloxy)quinolone
4-(2,3-dimethoxynaphthalen-5-yloxy)benzenamine
BenzeMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]-
4-[(6,7-diMethoxy-4-quinolinyl)oxy]-BenzenaMine
[4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl]amine
BenzenaMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]-
4-[(6,7-dimethoxyquinolin-4-yl)oxy]aniline
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline | [Molecular Formula]
C17H16N2O3 | [MDL Number]
MFCD19685633 | [MOL File]
190728-25-7.mol | [Molecular Weight]
296.321 |
| Chemical Properties | Back Directory | [Melting point ]
211.0 to 215.0 °C | [Boiling point ]
481.8±45.0 °C(Predicted) | [density ]
1.246±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly, Sonicated), Methanol (Slightly) | [form ]
powder to crystal | [pka]
6.79±0.30(Predicted) | [color ]
Light yellow to Brown | [InChI]
InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-8-7-15(13)22-12-5-3-11(18)4-6-12/h3-10H,18H2,1-2H3 | [InChIKey]
VXEQRXJATQUJSN-UHFFFAOYSA-N | [SMILES]
C1(N)=CC=C(OC2C3C(N=CC=2)=CC(OC)=C(OC)C=3)C=C1 |
| Hazard Information | Back Directory | [Uses]
4-(6,7-Dimethoxy-Quinolin-4-Yloxy)-Phenylamine is used in preparation of Cabozantinib Defluorination impurity. | [Chemical Reactivity]
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline is a primary alcohol that has been shown to catalyze the reaction of potassium carbonate with an alkali metal hydroxide to produce potassium. It has also been shown to be a base catalyst for the reaction of cyclopropanecarboxylic acid with an alcohol ester to produce high yield.
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