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ChemicalBook--->CAS DataBase List--->1890169-95-5

1890169-95-5

1890169-95-5 Structure

1890169-95-5 Structure
IdentificationBack Directory
[Name]

UPGL00004
[CAS]

1890169-95-5
[Synonyms]

UPGL00004
[Molecular Formula]

C25H26N8O2S2
[MOL File]

1890169-95-5.mol
[Molecular Weight]

534.66
Chemical PropertiesBack Directory
[density ]

1.460±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

9.23±0.50(Predicted)
[color ]

Off-white to gray
Hazard InformationBack Directory
[Biological Activity]

UPGL00004 is a potent glutaminase C (GAC) inhibitor with IC50 of 29 nM, more selective for GAC than GLS2.
[in vitro]

Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab effectively inhibited triple-negative breast cancer cell growth and tumor growth.

[in vivo]

Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab inhibited tumor growth in a human xenograft model of breast cancer.

[target]

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 29 nM
TargetValue
glutaminase C
(Cell-free assay)
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