| Identification | Back Directory | [Name]
AM-0902 | [CAS]
1883711-97-4 | [Synonyms]
AM0902
AM-0902
CS-2717
AM-0902
(AM 0902
1-[[3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-7-methylpurin-6-one
1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one
1-({3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl}methyl)-7-methyl-1,7-dihydro-6H-purin-6-one
6H-Purin-6-one, 1-[[3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl- | [Molecular Formula]
C17H15ClN6O2 | [MDL Number]
MFCD31579854 | [MOL File]
1883711-97-4.mol | [Molecular Weight]
370.79 |
| Chemical Properties | Back Directory | [Melting point ]
190 - 197°C | [Boiling point ]
657.3±65.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Very Slightly) | [form ]
Solid | [pka]
2.36±0.50(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
AM 0902 is a potent, selective antagonist of TRPA1 (transient receptor potential A1), which has been shown to play a large role in biological pathways associated with pain. | [Biological Activity]
AM-0902 (AMG0902) is a potent and selective transient receptor potential A1 (TRPA1) antagonist (rat/human TRPA1 IC50 = 71/131 nM against AITC-induced 45Ca2+ influx in respective CHO transfectants with [AITC] = EC90 = 3 μM/hTRPA1 or 35 μM/rTRPA1; human/r at IC50 = 24/20 nM by FLIPR) with little potency against human TRPV1/4human CYP3A4/2D6r at TRPV1/3r at TRPM8or mouse NaV1.7. AM-0902 effectively reduces AITC-induced flinching in a r at pain model (by 65% and 85%respectivelywith 10 or 30 mg/kg AM-0902 p.o. 1 hr prior to AITC injection) with good pharmacokinetic propertiesoral availability and brain exposure (F = 60%B/P = 0.2; 30 mg/kg p.o. in rats) in vivo. | [storage]
Store at -20°C |
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| Company Name: |
Henan Alfachem Co.,Ltd.
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| Tel: |
0371-0371-55051623 18137891487 |
| Website: |
http://www.approvedhomemanagement.com/supplier/14555231/ |
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