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ChemicalBook--->CAS DataBase List--->187947-37-1

187947-37-1

187947-37-1 Structure

187947-37-1 Structure
IdentificationBack Directory
[Name]

AA-5-HT
[CAS]

187947-37-1
[Synonyms]

AA-5-HT
ARACHIDONYLSEROTONIN
ARACHIDONOYL SEROTONIN
N-Arachidonoylserotonin
N-ARACHIDONYL-5-HYDROXYTRYPTAMINE
Arachidonoylserotonin >=98% (HPLC), oil
N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
N-[2-(5-HYDROXY-1H-INDOL-3-YL)ETHYL]-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
(5Z,8Z,11Z,14Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]icosa-5,8,11,14-tetraenamide
N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenamide
5,8,11,14-Eicosatetraenamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-, (5Z,8Z,11Z,14Z)-
AA-5-HT, N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenamide
[Molecular Formula]

C30H42N2O2
[MDL Number]

MFCD02179189
[MOL File]

187947-37-1.mol
[Molecular Weight]

462.67
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[solubility ]

DMSO: >10mg/mL
[form ]

oil
[color ]

yellow
[Sensitive ]

Air & Light Sensitive
Safety DataBack Directory
[Symbol(GHS) ]


GHS02,GHS07
[Signal word ]

Danger
[Hazard statements ]

H225-H319-H336
[Precautionary statements ]

P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
[WGK Germany ]

3
Hazard InformationBack Directory
[Definition]

ChEBI: N-arachidonoylserotonin is an N-acylserotonin obtained by formal condensation of the carboxy group of arachidonic acid with the primary amino group of serotonin. It has a role as a human metabolite, a signalling molecule, an antioxidant, an anti-inflammatory agent, an anticonvulsant, a capsaicin receptor antagonist and an EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor. It is a member of phenols and a N-acylserotonin. It is functionally related to an arachidonic acid.
[Biological Activity]

Dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC 50 values are 5.6 μ M and 37-40 nM for FAAH and TRPV1 respectively). Inactive at cPLA 2 , CB 1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.
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