| Identification | Back Directory | [Name]
BIO 1211 | [CAS]
187735-94-0 | [Synonyms]
BIO 1211
L-Proline, N-[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-α-aspartyl-L-valyl-
(2S)-1-[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carboxylicacid | [Molecular Formula]
C36H48N6O9 | [MDL Number]
MFCD02259692 | [MOL File]
187735-94-0.mol | [Molecular Weight]
708.8 |
| Chemical Properties | Back Directory | [Boiling point ]
962.2±65.0 °C(Predicted) | [density ]
1.306±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 2 mg/ml in 0.2M PBS | [form ]
solid | [pka]
3.40±0.20(Predicted) | [color ]
White | [Water Solubility ]
Soluble to 2 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
BIO 1211 is a selective, high affinity α4β1 (VLA-4) inhibitor. | [Biological Activity]
BIO 1211 is a selectivetight-binding α4β1 (VLA-4very late antigen-4; koff = 1.4 x 10-4/sKD = 70 pM) integrin antagonist (VCAM-Ig Jurk at surface binding IC50 = 1 nM; integrin-mediated cell adhesion IC50 = 4 nM/α4β12 μM/α4β7>100 μM/α1β1α5β1α6β1αLβ2αIIBβ3) based on the Leu-Asp-Val (LDV) sequence from the alternatively spliced connecting segment-1 (CS-1) of fibronectin (aa 1980-1983). In addition to probing α4β1-mediated cellular responsesBIO 1211 is also widely used in animal disease models in vivoincluding MS (5-10 mg/kg; murine EAE) and asthma (1-10 mg/kg via intranasal or nebulizer to miceratssheep; 3 mg/sheep iv.). | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|