| Identification | Back Directory | [Name]
Ilorasertib hydrochloride | [CAS]
1847485-91-9 | [Synonyms]
ABT-348 hydrochloride
Ilorasertib hydrochloride
ILORASERTIB HYDROCHLORIDE (ABT-348 HYDROCHLORIDE) | [Molecular Formula]
C25H22ClFN6O2S | [MDL Number]
MFCD32201158 | [MOL File]
1847485-91-9.mol | [Molecular Weight]
525 |
| Hazard Information | Back Directory | [Description]
Ilorasertib hydrochloride (ABT-348 hydrochloride) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib hydrochloride (ABT-348 hydrochloride) also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively[1]. | [References]
[1]. Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27. |
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