| Identification | Back Directory | [Name]
GLS1 Inhibitor | [CAS]
1832646-52-2 | [Synonyms]
GLS1 Inhibitor,GLS-1 Inhibitor
4-thiadiazol-2-yl]-benzeneacetamide
αS-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1
ΑS-METHOXY-N-[5-[[(3R)-1-(3-PYRIDAZINYL)-3-PYRROLIDINYL]AMINO]-1;3;4-THIADIAZOL-2-YL]-BENZENEACETAMIDE
Benzeneacetamide, α-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1,3,4-thiadiazol-2-yl]-, (αS)- | [Molecular Formula]
C19H21N7O2S | [MOL File]
1832646-52-2.mol | [Molecular Weight]
411.48 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50 = 0.021 μM). It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cells in vitro (GI50 = 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model. |
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DC Chemicals
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