| Identification | Back Directory | [Name]
Ubiquitination-IN-1 | [CAS]
1819330-15-8 | [Synonyms]
Ubiquitition-IN-1
Ubiquitination-IN-1 | [Molecular Formula]
C21H14F3N3O2S | [MDL Number]
MFCD31617017 | [MOL File]
1819330-15-8.mol | [Molecular Weight]
429.42 |
| Chemical Properties | Back Directory | [Boiling point ]
569.2±60.0 °C(Predicted) | [density ]
1.441±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 83.33 mg/mL (194.06 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
6.58±0.30(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Biological Activity]
Ubiquitination-IN-1 (compound 24) is a ubiquitination and Cksl-Skp2 protein-protein interaction (IC50=0.17 μM) inhibitor. Ubiquitination-IN-1 increases levels of p27. Ubiquitination-IN-1 has the potential for treatment disease by blocking the degradation of tumor suppressors[1].
Ubiquitination-IN-1 inhibits A549 and HT1080 cells with IC50s of 0.91 and 0.4 μM, respectively[1]. | [References]
[1]. David Carroll, et al.Quinoline derivatives useful as ubiquitination inhibitors. WO2016025779A1. |
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