| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
1818864-51-5 | [Synonyms]
MC-VA-PABC-MMAE
Mal-C5-Val-Ala-PAB-MMAE | [Molecular Formula]
C65H99N9O14 | [Molecular Weight]
1230.53 |
| Chemical Properties | Back Directory | [Boiling point ]
1289.9±65.0 °C(Predicted) | [density ]
1.181±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 100 mg/mL (81.27 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.36±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
MC-VA-PABC-MMAE is a drug-linker conjugate for ADC. MC-VA-PABC-MMAE contains the ADCs linker (peptide MC-VA-PABC) and a potent tubulin polymerization inhibitor MMAE [1][2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. | [References]
[1]. Wang Y, et al. Development of applicable thiol-linked antibody-drug conjugates with improved stability and therapeutic index. Drug Deliv. 2022 Dec;29(1):754-766. [2]. Cazzamalli S, et al. Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma. J Control Release. 2017 Jan 28;246:39-45. |
|
|