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ChemicalBook--->CAS DataBase List--->1803026-54-1

1803026-54-1

1803026-54-1 Structure

1803026-54-1 Structure
IdentificationBack Directory
[Name]

Sitagliptin Impurity 12
[CAS]

1803026-54-1
[Synonyms]

(Z)-1-(3-(trifluoromethyl)
Sitagliptin EP Impurity 12
2-Buten-1-one, 1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (2Z)-
[Molecular Formula]

C16H12F6N4O
[MOL File]

1803026-54-1.mol
[Molecular Weight]

390.28
Chemical PropertiesBack Directory
[Boiling point ]

517.5±60.0 °C(Predicted)
[density ]

1.52±0.1 g/cm3(Predicted)
[pka]

-0.06±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one is an intermediate in the synthesis of 3-Desamino-2,3-dehydro Sitagliptin (D281985),an impurity of Sitagliptin (S491000). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.
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