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ChemicalBook--->CAS DataBase List--->180272-45-1

180272-45-1

180272-45-1 Structure

180272-45-1 Structure
IdentificationBack Directory
[Name]

(1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline
[CAS]

180272-45-1
[Synonyms]

Solifenacin Impurity 2
Solifenacin Impurity 42
(S)-quinuclidin-3-yl acetate
Solifenacin Related Compound 9
Solifenacin Succinate interMediate G
(1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-1-Phenyl-1,2,3,4-tetrhydroisoquinoline
(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-1,2,3,4-Tetrahydro-1-phenylisoquinoline
(1R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
(1R)-1,2,3,4-Tetrahydro-1-phenyl-isoquinoline
(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline(W.S)
Isoquinoline, 1,2,3,4-tetrahydro-1-phenyl-, (1R)-
(R)-1,2,3,4-Tetrahydro-1-phenylisoquinoline,99%e.e.
TIANFU-CHEM (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline
Solifenacin impurity 10/Solifenacin R Isomer/(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
[Molecular Formula]

C15H15N
[MOL File]

180272-45-1.mol
[Molecular Weight]

209.286
Chemical PropertiesBack Directory
[Melting point ]

78-79℃
[density ]

1.065
[storage temp. ]

2-8°C
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the counterpart to (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, the latter enantiomer being a key intermediate in the preparation of Solifenacin (S676700), an antimuscarinic agent. Since (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is produced as a by-product, it has been suggested that it should be recycled in order to obtain the S enantiomer on a larger scale. (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is also used as a reagent to prepare quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives, compounds that act as muscarinic receptor antagonists.
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