| Identification | Back Directory | [Name]
IKE) | [CAS]
1801530-11-9 | [Synonyms]
IKE)
Ferroptosis inducer IKE
Imidazole ketone erastin
Imidazole ketone erastin
(Ferroptosis inducer IKE
IMIDAZOLE KETONE ERASTIN;FERROPTOSIS INDUCER IKE;IKE
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]- | [Molecular Formula]
C35H35ClN6O5 | [MOL File]
1801530-11-9.mol | [Molecular Weight]
655.14 |
| Chemical Properties | Back Directory | [Boiling point ]
886.5±75.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 10mg/mL,DMSO: 1mg/mL,DMSO:PBS (pH 7.2) (1:2): 0.25mg/mL | [form ]
A crystalline solid | [pka]
6.12±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Imidazole ketone erastin is an inducer of ferroptosis. It inhibits glutamate release in human CCF-STTG1 astrocytoma cells (IC50 = 30 nM), indicating inhibition of the system xc- cystine/glutamate transporter. Imidazole ketone erastin increases production of lipid reactive oxygen species (ROS) in SUDHL6 diffuse large B cell lymphoma (DLBCL) cells in a concentration-dependent manner, as well as reduces glutathione (GSH) levels in these cells (IC50 = 34 nM). It inhibits the growth of HT-1080 fibrosarcoma cells (GI50 = 310 nM) as well as HRASG12V-overexpressing BJeLR cells (IC50 = 3 nM). Imidazole ketone erastin (23 and 40 mg/kg) reduces tumor growth in an SUDHL6 mouse xenograft model. | [Uses]
PUN30119 is potent, metabolically stable inhibitor of system xc. | [storage]
Store at -20°C |
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