| Identification | Back Directory | [Name]
1-(3-Methoxypropyl)-4-piperidinamine | [CAS]
179474-79-4 | [Synonyms]
Prucalopride intermediateB
4-AMino-1-(3-Methoxypropy...
Prucalopride Succinate iMpuritO
3-methoxy propyl piperidinamine
1-(3-Methoxypropyl)-4-piperidimine
1-(3-Methoxypropyl)piperidin-4-aMine
1-(3-Methoxypropyl)-4-piperidinamine
4-AMino-1-(3-Methoxypropyl)piperidine
Prucalopride Succinate interMediate B
4-PiperidinaMine, 1-(3-Methoxypropyl)-
PRUCALOPRIDE SUCCINATE CAS 179474-85-2 INTERMEDIATES
1-(3-Methoxypropyl)-4-piperidinamine (Plucabili impurity) | [EINECS(EC#)]
431-950-8 | [Molecular Formula]
C9H20N2O | [MDL Number]
MFCD11104531 | [MOL File]
179474-79-4.mol | [Molecular Weight]
172.27 |
| Chemical Properties | Back Directory | [Boiling point ]
249℃ | [density ]
0.946 | [Fp ]
105℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
10.49±0.20(Predicted) | [InChI]
InChI=1S/C9H20N2O/c1-12-8-2-5-11-6-3-9(10)4-7-11/h9H,2-8,10H2,1H3 | [InChIKey]
HIXAJGFVNMKLML-UHFFFAOYSA-N | [SMILES]
N1(CCCOC)CCC(N)CC1 |
| Hazard Information | Back Directory | [Uses]
1-(3-Methoxypropyl)-4-piperidinamine is a useful synthetic intermediate in the synthesis of Prucalopride Succinate (P838950); a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe. | [Synthesis]
N-(1-(3-methoxypropyl)piperidin-4-yl)acetamide (10.72g, 0.05mol) was added to HCl-methanol solution (0.5M, 180ml), and the temperature was controlled at 2025°C After the reaction was detected, it was filtered, and the filter cake was washed with dichloromethane and dried to obtain 1-(3-Methoxypropyl)-4-piperidinamine with a yield of 96.4% and a purity of 99.7%. |
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