| Identification | Back Directory | [Name]
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- | [CAS]
176957-55-4 | [Synonyms]
CS-1839
CCT007093
CCTOO7093
CCT-007093; CCT 007093; CCT007093
2,5-Bis(2-thienylmethylene)-cyclopentanone
(2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone
2,5-bis(2-thienylMethylene)-, (E,E)-Cyclopentanone
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
(2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentanone
Cyclopentanone, 2,5-bis(2-thienylmethylene)-, (2E,5E)-
(2Z,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one
(2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone CCT007093 | [Molecular Formula]
C15H12OS2 | [MDL Number]
MFCD00121546 | [MOL File]
176957-55-4.mol | [Molecular Weight]
272.39 |
| Hazard Information | Back Directory | [Uses]
Acts as a PPM1D inhibitor | [Biological Activity]
cct007093 is a small-molecule chemical inhibitor of ppm1d with ic50 value of 8.4μm [1].cct007093 is a thienylidene cyclopentanone and shows a potent inhibition of ppm1d in the in vitro assay when using the recombinant phospho-p38 as a substrate. in cellular assay, cct007093 shows specificity for mcf-7 cells over hela cells. it reduces 40% viability of the cells after 2 days. it is found that the cell death induced by cct007093 is dependent on p38 kinase activity. cct007093 mimics the effect of ppm1d rnai in activating p38 kinase. it induces p38 phosphorylation at 4 h post-exposure in mcf-7 cells and the loss of viability can be rescued by sb203580, the specific p38 inhibitor [1]. | [target]
WIP1 | [References]
[1] rayter s, elliott r, travers j, rowlands mg, richardson tb, boxall k, jones k, linardopoulos s, workman p, aherne w, lord cj, ashworth a. a chemical inhibitor of ppm1d that selectively kills cells overexpressing ppm1d. oncogene. 2008 feb 14;27(8):1036-44. |
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