| Identification | Back Directory | [Name]
SB 223412 | [CAS]
174636-32-9 | [Synonyms]
CS-1123
SB 223412
Talnetant (SB 223412)
SB-223412; SB223412; SB 223412
3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
(S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide
3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
4-Quinolinecarboxamide, 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-
(-)-3-Hydroxy-2-phenyl-N-[1(S)-phenylpropyl]quinoline-4-carboxamide
(-)-(S)-N-(alpha-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxaMide
Talnetant/(S)-3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
TALNETANT//SB223412//3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxaMide | [Molecular Formula]
C25H22N2O2 | [MDL Number]
MFCD00944075 | [MOL File]
174636-32-9.mol | [Molecular Weight]
382.45 |
| Chemical Properties | Back Directory | [Melting point ]
125.1-126.2℃ | [Boiling point ]
580.4±50.0 °C(Predicted) | [density ]
1.212±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: soluble25mg/mL, clear | [form ]
powder | [pka]
6.70±0.50(Predicted) | [color ]
white to beige | [optical activity]
[α]/D -25 to -31°, c = 0.5 in methanol |
| Hazard Information | Back Directory | [Description]
Talnetant is an antagonist of the neurokinin-3 (NK3) receptor (Ki = 1 nM). It is selective for NK3 over NK1 and NK2 receptors (Kis = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B in HEK293 cells expressing human NK3 receptors (IC50 = 16.6 nM). It inhibits contractions induced by the NK3 receptor agonist senktide in isolated rabbit iris sphincter muscle (pD2 = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs. | [Uses]
Talnetant acts as a neurokinin 3 (NK3) receptor antagonist used as an antispychotic. |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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