| Identification | Back Directory | [Name]
1,2-Benzenediol, 4-(methylnitrosoamino)- | [CAS]
173043-84-0 | [Synonyms]
APOBEC3G inhibitor MN30
1,2-Benzenediol, 4-(methylnitrosoamino)-
N-(3,4-dihydroxyphenyl)-N-methylnitrous amide | [Molecular Formula]
C7H8N2O3 | [MOL File]
173043-84-0.mol | [Molecular Weight]
168.15 |
| Hazard Information | Back Directory | [Uses]
Methyl-3,4-dephostatin has been used as:
- an inhibitor for methyltransferases
- a kinase-related inhibitor for human transglutaminase
- a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein
| [Biological Activity]
Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatinit can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).''Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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