| Identification | Back Directory | [Name]
PMPA(NAALADaseinhibitor) | [CAS]
173039-10-6 | [Synonyms]
2-PMPA
CS-2454
NAALADASEINHIBITOR
PMPA(NAALADaseinhibitor)
2-PMPA(NAALADaseinhibitor)
Pentanedioic acid, 2-(phosphonomethyl)-
2-(Phosphonomethyl)pentane-1,5-dioicacid | [Molecular Formula]
C6H11O7P | [MDL Number]
MFCD00940167 | [MOL File]
173039-10-6.mol | [Molecular Weight]
226.12 |
| Chemical Properties | Back Directory | [Boiling point ]
538.8±60.0 °C(Predicted) | [density ]
1.658±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
Soluble to 100 mM in sterile | [form ]
powder | [pka]
2.06±0.10(Predicted) | [color ]
white to beige | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
2-(Phosphonomethyl)pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia. | [Biological Activity]
Highly potent and selective inhibitor of? glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO). | [Biochem/physiol Actions]
2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII). | [storage]
Desiccate at RT |
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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