| Identification | Back Directory | [Name]
Doxycycline monohydrate | [CAS]
17086-28-1 | [Synonyms]
Power v1
NSC-56228
Strong v1
Doxycyeline HCL
Doxycycline USP
DOXYCYCLINE HYDRATE
DOXYCYCLINE MONOHYDRATE
Doxycycline Monohydrate (100 mg)
Doxycycline monohydrate USP/EP/BP
6-Deoxy-5-oxytetracycline Monohydrate
Doxycycline Monohydrate/Doxycycline base
Doxycycline Hycate BP2000/Ph Eur 4/USP25
DoxycyclineHyclate/Monohydrate24390-14-5/Mono
4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrote
4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NA
4-(DiMethylaMino)-3,5,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxaMide hydrate
2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione hydrate
4-(DIMETHYLAMINO)-1,4,4 ALPHA,5,5 ALPHA,6,11,12 ALPHA-OCTAHYDRO-3,5,10,12,12 ALPHA-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NAPHTHACENECARBOXAMIDE, MONOHYDRATE
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrate, (4S,4aR,5S,5aR,6R,12aS)- | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C22H26N2O9 | [MDL Number]
MFCD02682958 | [MOL File]
17086-28-1.mol | [Molecular Weight]
462.45 |
| Chemical Properties | Back Directory | [Appearance]
Yellow, crystalline powder. | [Melting point ]
167-168℃ | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble1mg/mL | [form ]
powder or crystals | [color ]
Light Yellow | [Water Solubility ]
Soluble in ethanol or methanol. Sparingly soluble in water.Soluble in dilute acids, alkali hydroxides and dimethyl sulfoxide. | [CAS DataBase Reference]
17086-28-1 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow, crystalline powder. | [Uses]
Tetracycline antibacterial. | [Definition]
ChEBI: The monohydrate form of doxycycline. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary
isease (COPD), and adult periodontitis. | [Brand name]
Doxychel (Rachelle); Monodox (Oclassen); Oracea (CollaGenex); Vibramycin (Pfizer). | [Description]
Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a semi-synthetic tetracycline. Doxycycline penetrates the bacterial cell and interferes with the protein biosynthesis, stopping the process. Other microorganisms are also sensitive to the antibiotic activity of Doxycycline, such as Mycoplasma, Chlamydia and Ricketsiae. Resistance to antibiotics of the tetracycline family is primarily due to inhibition of transport of the drug into the cell or by increasing antibiotic efflux. The biological mechanism is mainly through plasmid mediation but it may also occur by chromossomal alteration.? | [Application]
In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
It has also been used as an antimicrobial agent. | [Indications]
Doxycycline monohydrate (Vibramycin Monohydrate, Monodox, Mondoxyne NL) is a moderately priced drug used to treat many kinds of infections, like dental, skin, respiratory, and urinary tract infections. It also treats acne, Lyme disease, malaria, and certain sexually transmitted infections. This drug is more popular than comparable drugs. It is available in multiple brand and generic versions. Generic doxycycline monohydrate is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The lowest GoodRx price for the most common version of doxycycline monohydrate is around $6.02, 80% off the average retail price of $30.66. Compare tetracycline antibiotics. | [Biological Activity]
Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome. | [storage]
Store at -20°C |
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