| Identification | Back Directory | [Name]
I-191
(I191) | [CAS]
1690172-25-8 | [Synonyms]
I-191
I-191
(I191)
I-191,Inhibitor,I191,inhibit,I 191,Protease Activated Receptor (PAR),Thrombin receptors
4-(8-(tert-Butyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one
2-Piperazinone, 4-[[8-(1,1-dimethylethyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazin-2-yl]carbonyl]-3,3-dimethyl- | [Molecular Formula]
C23H26FN5O2 | [MDL Number]
MFCD32062778 | [MOL File]
1690172-25-8.mol | [Molecular Weight]
423.48 |
| Chemical Properties | Back Directory | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 8.33 mg/mL (19.67 mM; Need ultrasonic)| | [form ]
Solid | [pka]
13.69±0.40(Predicted) | [color ]
White to gray | [Water Solubility ]
Water : < 0.1 mg/mL (insoluble) |
| Hazard Information | Back Directory | [Uses]
I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1]. | [IC 50]
PAR2 | [storage]
Store at -20°C | [References]
[1] Jiang Y, et al. A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells. J Pharmacol Exp Ther. 2018 Feb;364(2):246-257. DOI:10.1124/jpet.117.245027 |
|
|