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ChemicalBook--->CAS DataBase List--->1689540-62-2

1689540-62-2

1689540-62-2 Structure

1689540-62-2 Structure
IdentificationBack Directory
[Name]

αvβ1 integrin-IN-1
[CAS]

1689540-62-2
[Synonyms]

αvβ1 integrin-IN-1
αvβ1 integrin-IN-1
[Molecular Formula]

C26H34N6O6S
[MDL Number]

MFCD30747846
[MOL File]

1689540-62-2.mol
[Molecular Weight]

558.65
Chemical PropertiesBack Directory
[density ]

1.42±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 50 mg/mL
[form ]

Solid
[pka]

3.59±0.10(Predicted)
[color ]

White to off-white
Spectrum DetailBack Directory
[Spectrum Detail]

αvβ1 integrin-IN-1(1689540-62-2)1HNMR
Hazard InformationBack Directory
[Biological Activity]

αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibrotic effects[1]. αvβ1 integrin-IN-1 (Compound C8) significantly reduces the fibrotic markers in mouse model for liver and lung fibrosis[1].
[References]

[1]. Reed NI, et al. Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Aug 30;7(10):902-907.
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