| Identification | Back Directory | [Name]
1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT | [CAS]
168021-79-2 | [Synonyms]
CPI22
CPI-22
CPI 22
CXY059
OKN007
D03875
HPN-07
CS-791
OKN-007
CXY-059
CXY 059
OKN 007
ARL16556
Cerovive
ARL-16556
ARL 16556
Disufenton
NXY059/NXY-059
disufenton sodium
Cerovive(NXY-059)
NXY-059(Cerovive)
NXY-059(Disufentonsodium)
NXY 059 (CEROVIVE);NXY059
Disufenton sodium (NXY-059)
Disufenton sodium (usan/inn)
Disufenton sodiuM (NXY 059,Cerovive)
4-[[(1,1-Dimethylethyl)oxoimino]methyl]-1,3-benzenedisulfonicaciddisodiumsalt
Disodium,4-[(Z)-[tert-butyl(oxido)azaniumylidene]methyl]benzene-1,3-disulfonate
1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT
1,3-Benzenedisulfonic acid, 4-[[(1,1-dimethylethyl)imino]methyl]-, N-oxide, disodium salt
NXY059; NXY 059; NXY-059; CXY 059; CXY059; CXY-059; OKN007; OKN-007; OKN 007; ARL 16556; ARL16556; ARL-16556; CPI-22; CPI22; CPI 22; CEROVIVE; DISUFENTON SODIUM | [Molecular Formula]
C11H14NNa2O7S2 | [MDL Number]
MFCD09833648 | [MOL File]
168021-79-2.mol | [Molecular Weight]
382.341 |
| Hazard Information | Back Directory | [Uses]
A free radical trapping compound | [Uses]
Cerovive (NXY-059) is a novel nitrone, shows efficacious neuroprotective effects that prevents ischemic damage by trapping free radicals. Neuroprotectant. | [Biological Activity]
Free radical trapping agent. Reduces infarct size and preserves brain function in several animal models of acute ischemic stroke. Neuroprotectant. | [Biochem/physiol Actions]
Originally characterized for its NO-mimicking activity in preventing peroxynitrite formation and in vivo neuroprotective efficacy in animal models of cerebral ischemia (100 mg/kg i.v. in rabbits; 30-60 mg/kg plus 30-60 mg/kg/h i.v. or 50 mg/kg plus 8.8 mg/kg/h s.c. in rats; 28 mg/kg plus 16 mg/kg/h i.v. in monkeys), OKN-007 (HPN-07, NXY-059) is an orally available α-phenyl-tert-butylnitrone (PBN) derivative that is also shown to exhibit sulfatase 2 (SULF2) inhibitory activity and anticancer efficacy both in cultures (effective conc. 170-200 μM in Huh7 heptoma cultures) and in several rodent glioma models in vivo (C6, RG2, and GL261; 75 mg/kg/day for rats and 168 mg/kg/day for mice via drinking water). | [storage]
Store at -20°C | [References]
[1] kuroda s1, tsuchidate r, smith ml, maples kr, siesj? bk. |
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