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ChemicalBook--->CAS DataBase List--->16777-42-7

16777-42-7

16777-42-7 Structure

16777-42-7 Structure
IdentificationBack Directory
[Name]

[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride
[CAS]

16777-42-7
[Synonyms]

D 563
Ildamen
Modacor
FDA 1576
OXYFEDRINE HCL
L-OXYFEDRINE HCL
Ildamen USP/EP/BP
L-Form hydrochloride
Oxyfedrine L-form HCl
OXYFEDRINEHYROCHLORIDE
l-Oxyfedrine hydrochloride
Oxyfedrine L-form hydrochloride
[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride
3-[[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-(3-methoxyphenyl)propan-1-one,hydrochloride
3-[[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-(3-methoxyphenyl)-1-propanone hydrochloride
(3R)-3-(((1S)-1-Hydroxy-1-phenylpropan-2-yl)amino)-3-methoxy-1-phenylpropan-1-one hydrochloride
[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride USP/EP/BP
[EINECS(EC#)]

240-828-1
[Molecular Formula]

C19H24ClNO3
[MDL Number]

MFCD01695148
[MOL File]

16777-42-7.mol
[Molecular Weight]

349.852
Chemical PropertiesBack Directory
[Melting point ]

192-194℃
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Originator]

Ildamen,Homburg,W. Germany ,1966
[Manufacturing Process]

45 grams of m-methoxy acetophenone, 8 grams of paraformaldehyde and 30.2 grams of 1 norephedrine were mixed with about 135 cc of isopropanol HCl solution to provide a pH of 4 and the mixture refluxed for 4 hours. The reaction mixture was cooled and the crystals filtered off on a suction filter. 3[1-phenyl-1-hydroxypropyl-(2)-amino]-1-(m-methoxyphenyl)-propanone-(1) HCl was obtained which after recrystallization from methanol had a MP of 190° to 193°C.
[Therapeutic Function]

Coronary vasodilator
Safety DataBack Directory
[Toxicity]

LD50 in mice (mg/kg): 29 i.v. (Hueller)
Spectrum DetailBack Directory
[Spectrum Detail]

[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride(16777-42-7)1HNMR
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