| Identification | Back Directory | [Name]
Indisulam | [CAS]
165668-41-7 | [Synonyms]
E-7070
D04522
ER-35744
INDISULAM
IndisulaM (E7070)
E7070;ER-35744;D04522
Indisulam >=98% (HPLC)
IndisulaM (E7070) (ER-35744)
N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
N1-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)-
1,4-Benzenedisulfonamide, N1-(3-chloro-1H-indol-7-yl)- | [Molecular Formula]
C14H12ClN3O4S2 | [MDL Number]
MFCD00945325 | [MOL File]
165668-41-7.mol | [Molecular Weight]
385.85 |
| Chemical Properties | Back Directory | [Melting point ]
242-243 °C (decomp)(Solv: ethanol (64-17-5); water (7732-18-5)) | [Boiling point ]
668.9±65.0 °C(Predicted) | [density ]
1.663±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO : 100 mg/mL (259.17 mM; Need ultrasonic) | [form ]
powder | [pka]
8.14±0.30(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Definition]
ChEBI: Indisulam is a chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor and an antineoplastic agent. It is a chloroindole, a sulfonamide and an organochlorine compound. | [Biochem/physiol Actions]
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition. | [storage]
Store at -20°C |
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