| Identification | Back Directory | [Name]
myelin oligodendrocyte glycoprotein peptide fragment 35-55 rat, mouse | [CAS]
163913-87-9 | [Synonyms]
MOG 35-55 amide
Myelin oligodendrocyte glycoprotein mouse rat 35-55
DNA (human 35-55-myelin-oligodendroglial glycoprotein MOG-specifying)
DNA (human 35-55-myelin-oligodendroglial glycoprotein MOG-specifying cDNA)
Deoxyribonucleic acid (human 35-55-myelin-oligodendroglial glycoprotein MOG-specifying)
Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 Rat, Mouse immunodominant epitope of MOG | [Molecular Formula]
C118H177N35O29S | [MDL Number]
MFCD02265607 |
| Hazard Information | Back Directory | [General Description]
Myelin oligodendrocyte glycoprotein (MOG) is a component of the central nervous system and present on the surface of oligodendrocytes and myelin. Its extracellular domain is widely used to generate an autoimmune animal model of multiple sclerosis. In rats, it is expressed in the hippocampus. | [Biochem/physiol Actions]
Induces experimental autoimmune encephalomyelitis in rodents; a single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination; immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP. |
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