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ChemicalBook--->CAS DataBase List--->1638241-89-0

1638241-89-0

1638241-89-0 Structure

1638241-89-0 Structure
IdentificationBack Directory
[Name]

STING-Inducer-1
[CAS]

1638241-89-0
[Synonyms]

MIW815
ML RR-S2 CDA
STING-Inducer-1
ML RR-S2 CDA;MIW815;STING-INDUCER-1
ML RR-S2 CDA;STING-INDUCER-1;1638241-89-0
Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide
[Molecular Formula]

C20H24N10O10P2S2
[MDL Number]

MFCD28900737
[MOL File]

1638241-89-0.mol
[Molecular Weight]

690.54
Chemical PropertiesBack Directory
[Boiling point ]

1020.8±75.0 °C(Predicted)
[density ]

2.43±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 2 mg/mL (2.90 mM)
[form ]

Solid
[pka]

-0.67±0.70(Predicted)
[color ]

White to off-white
[InChIKey]

IZJJFUQKKZFVLH-UUXHIKLWNA-N
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

ML-RR-S2-CDA is a stimulator of interferon genes (STING) agonist for cancer treatment.
[Biological Activity]

ADU-S100 (MIW815) is an activator of stimulator of interferon genes (STING) with potent antitumor and immune activity.
[in vivo]

ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%.

[target]

STING

[storage]

Store at -20°C
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