| Identification | Back Directory | [Name]
PF-06446846 | [CAS]
1632250-49-7 | [Synonyms]
PF-6446846
PF-06446846
Threonine proteases,PF06446846,Inhibitor,80S ribosome,Selective,PF 06446846,Ser/Thr Protease,Serine proteases,Rat bone marrow,Huh7,inhibit,Serine endopeptidases,PF-06446846 | [Molecular Formula]
C22H20ClN7O | [MDL Number]
MFCD32182630 | [MOL File]
1632250-49-7.mol | [Molecular Weight]
433.89 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 87 mg/mL (200.51 mM);Ethanol: 87 mg/mL (200.51 mM) | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Definition]
ChEBI: PF-06446846 is a triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. It has a role as an antilipemic drug and an EC 3.4.21.61 (kexin) inhibitor. It is a monochloropyridine, a member of piperidines, a tertiary carboxamide, a member of benzamides and a triazolopyridine. |
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