| Identification | Back Directory | [Name]
Praliciguat | [CAS]
1628730-49-3 | [Synonyms]
IW-1973
Praliciguat
Praliciguat,IW 1973,Guanylate Cyclase,Inhibitor,IW1973,inhibit
2-Propanol, 1,1,1,3,3,3-hexafluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]-4-pyrimidinyl]amino]methyl]- | [Molecular Formula]
C21H14F8N6O2 | [MDL Number]
MFCD32062661 | [MOL File]
1628730-49-3.mol | [Molecular Weight]
534.36 |
| Chemical Properties | Back Directory | [Boiling point ]
588.5±50.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [solubility ]
DMSO : 250 mg/mL (467.85 mM; Need ultrasonic) | [form ]
Solid | [pka]
8.99±0.29(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Definition]
ChEBI: Praliciguat is a member of the class of pyrazoles that is 5-fluoro-2-(1H-pyrazol-3-yl)pyrimidine which is substituted by a 2-fluorobenzyl group at position 1, 1,2-oxazol-3-yl group at position 5, and by a [3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]nitrilo group at position 4. It is a soluble guanylate cyclase stimulator under clinical development for the treatment of heart failure with preserved ejection fraction. It has a role as a soluble guanylate cyclase activator, an anti-inflammatory agent, a vasodilator agent and an antihypertensive agent. It is a member of isoxazoles, a member of pyrazoles, an organofluorine compound, an aminopyrimidine, a tertiary alcohol, a secondary amino compound and a member of monofluorobenzenes. |
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