| Identification | Back Directory | [Name]
RET Kinase inhibitor 1 | [CAS]
1627856-64-7 | [Synonyms]
CS-2597
GSK3179106
GSK-3179106
RET Kinase inhibitor 1
c-RET inhibitor GS3179106
Benzeneacetamide, 4-(4-ethoxy-1,6-dihydro-6-oxo-3-pyridinyl)-2-fluoro-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]- | [Molecular Formula]
C22H21F4N3O4 | [MDL Number]
MFCD30747847 | [MOL File]
1627856-64-7.mol | [Molecular Weight]
467.41 |
| Chemical Properties | Back Directory | [Boiling point ]
670.1±55.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO:81.0(Max Conc. mg/mL);173.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM)
Ethanol:15.5(Max Conc. mg/mL);33.16(Max Conc. mM) | [form ]
A crystalline solid | [pka]
10.30±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
GSK3179106 is an inhibitor of rearranged during transfection (RET) kinase (IC50 = 0.4 nM). It is selective for RET kinase over VEGF receptor 2 (VEGFR2/KDR; IC50 = 109 nM). GSK3179106 reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at a dose of 10 mg/kg twice per day. |
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| Company Name: |
Cool Pharm, Ltd
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| Tel: |
021-60455363 18019463053 |
| Website: |
http://www.coolpharm.com |
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