| Identification | Back Directory | [Name]
PH11 | [CAS]
1627843-95-1 | [Synonyms]
PH11
Benzoic acid, 2-[[4-[(3,4,5-trimethoxyphenyl)amino]imidazo[1,2-a]-1,3,5-triazin-2-yl]amino]-, methyl ester | [Molecular Formula]
C22H22N6O5 | [MOL File]
1627843-95-1.mol | [Molecular Weight]
450.45 |
| Hazard Information | Back Directory | [Description]
PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL-induced apoptosis poses a huge problem in establishing clinically efficient TRAIL therapies. |
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