| Identification | Back Directory | [Name]
Imidazo[1,2-b]pyridazin-6-amine, N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thien-2-yl)- | [CAS]
1627729-62-7 | [Synonyms]
MLK-IN-1
Imidazo[1,2-b]pyridazin-6-amine, N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thien-2-yl)- | [Molecular Formula]
C23H20N4O3S | [MOL File]
1627729-62-7.mol | [Molecular Weight]
432.49 |
| Chemical Properties | Back Directory | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
4.34±0.30(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Biological Activity]
MLK-IN-1 is a potent, brain penetrant and specific mixed lineage kinase 3 (MLK-3) inhibitor, compound 68, extracted from patent US20140256733A1[1].
MLK-IN-1 (100 nM; pre-treatment 20 mins HIV-1 Tat) promotes continued axonogenesis in the presence of Tat-activated microglia and protects against effects of HIV-Tat in vitro[1]. | [References]
[1]. Val S. Goodfellow,et al.Mixed lineage kinase inhibitors and method of treatments. Patent US20140256733A1. |
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