| Identification | Back Directory | [Name]
N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide | [CAS]
1627138-52-6 | [Synonyms]
ML380
N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide | [Molecular Formula]
C23H25F3N4O3S | [MDL Number]
MFCD28386214 | [MOL File]
1627138-52-6.mol | [Molecular Weight]
494.53 |
| Chemical Properties | Back Directory | [Boiling point ]
661.2±65.0 °C(Predicted) | [density ]
1.388±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mg/mL (202.21 mM) | [form ]
Solid | [pka]
12.84±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
ML380 is a potent, isotype-selective and blood-brain barrier-permeable positive allosteric modulator (PAM) of M5 mAChR with EC50 values of 190 and 610 nM for human and rat M5, respectively. | [in vivo]
ML380 (1 mg/kg; iv) displays high clearance (66 mL/min/kg), a moderate volume of distribution (1.6 L/kg), and a short half-life (t 1/2 , 22 min) in rats. | [target]
IC50: 190 nM (hM5), 610 nM (rM5) | [storage]
Store at -20°C |
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