| Identification | Back Directory | [Name]
Propanamide, 3,3'-(octylimino)bis[N-phenyl- | [CAS]
1621535-90-7 | [Synonyms]
UCM-1336
3,3′-(Octylimino)bis[N-phenylpropanamide]
Propanamide, 3,3'-(octylimino)bis[N-phenyl- | [Molecular Formula]
C26H37N3O2 | [MOL File]
1621535-90-7.mol | [Molecular Weight]
423.59 |
| Chemical Properties | Back Directory | [Boiling point ]
644.2±40.0 °C(Predicted) | [density ]
1.089±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.43±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
UCM-1336 is a potent isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor ( IC50 = 2 μM). UCM-1336 improves survival in Ras-driven acute myeloid leukemia. UCM-1336 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. In addition, it induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia. |
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