Identification | Back Directory | [Name]
LOLJEILMPWPILA-WZDCOHRSSA-N | [CAS]
1621482-36-7 | [Synonyms]
LOLJEILMPWPILA-WZDCOHRSSA-N 8-iso-15-keto Prostaglandin F2β 8-iso-15-keto Prostaglandin F2.beta. 9β,11α-dihydroxy-15-oxo-(8β)-prosta-5Z,13E-dien-1-oic acid Prosta-5,13-dien-1-oic acid, 9,11-dihydroxy-15-oxo-, (5Z,8β,9β,11α,13E)- | [Molecular Formula]
C20H32O5 | [MOL File]
1621482-36-7.mol | [Molecular Weight]
352.47 |
Chemical Properties | Back Directory | [Boiling point ]
535.2±50.0 °C(Predicted) | [density ]
1.149±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml | [pka]
4.76±0.10(Predicted) |
Hazard Information | Back Directory | [Description]
8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α of non-enzymatic origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α. 8-iso-15-keto PGF2β is a potential metabolite of 8-iso PGF2β via the 15-hydroxy PG dehydrogenase pathway. There are no published reports on the formation or biological activity of 8-iso-15-keto PGF2β. | [Definition]
ChEBI: 8-iso-15-keto Prostaglandin F2beta is a prostanoid. |
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