| Identification | Back Directory | [Name]
Imidazo[1,2-a]pyrazine, 5-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-6-methyl-, (5R)- | [CAS]
1609583-15-4 | [Synonyms]
Imidazo[1,2-a]pyrazine, 5-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-6-methyl-, (5R)- | [Molecular Formula]
C21H16N4O2 | [MOL File]
1609583-15-4.mol | [Molecular Weight]
356.39 |
| Chemical Properties | Back Directory | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 200 mg/mL (561.20 mM; Need ultrasonic) | [form ]
Solid | [pka]
4.68±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
(R)-PF-06256142 is the R enantiomer of PF-06256142 with low active. PF-06256142 is a potent and selective orthosteric D1 receptor agonist that can reduce receptor desensitization relative to dopamine and other catechol-containing agonists[1]. | [References]
[1]. Davoren JE, et al. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem. 2018;61(24):11384-11397. |
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