| Identification | Back Directory | [Name]
Ibrutinib-biotin | [CAS]
1599432-18-4 | [Synonyms]
Ibrutinib-biotin
Ibrutinib-biotin-1
Reaxys ID: 26833452
Pentanediamide, N1-[4-[[4-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-4-oxo-2-buten-1-yl]methylamino]butyl]-N5-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]- | [Molecular Formula]
C56H80N12O9S | [MDL Number]
MFCD30496724 | [MOL File]
1599432-18-4.mol | [Molecular Weight]
1097.37 |
| Chemical Properties | Back Directory | [Boiling point ]
1288.9±65.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 50 mg/mL (45.56 mM) | [form ]
Solid | [pka]
13.90±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
Ibrutinib-biotin is a probe composed of Ibrutinib linked to biotin through a long chain linker. For details, please refer to Compound 1-5 in WO2014059368A1. It inhibits BTK with an IC50 value of 0.755-1.02 nM. | [in vitro]
Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC , BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine-mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells. | [target]
IC50: 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.57 nM (BMX), 5.99-6.92 nM (LCK), 33.8- 36.3 nM (Src), 0.187-0.198 μM (ITK), 5.34-4.87 μM (JAK3) | [storage]
Store at -20°C |
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Musechem
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ChemeGen 中國(guó)
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Pharma Affiliates
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